DHEA is the biological daughter of pregnenolone, a fat soluble, steroid hormone created primarily in the adrenal glands and in lesser amounts in the ovaries and testes, the brain and peripheral tissues such as the skin. As with all hormones, DHEA is a derivative of cholesterol metabolism, which serves as precursor to male and female sex hormones (androgens and estrogens). A large portion of DHEA is generated from adrenal synthesis, which is controlled by ACTH signaling (hypothalamus) and over time is severely reduced when cortisol is elevated or the patient is receiving treatment with corticosteroids. Some say DHEA drops off with age however as it’s probably more a matter of stress, “accumulated baggage”, that is at issue. Adrenals secrete it into the blood stream, where it is circulated in the form of DHEA-Sulfate (reservoir for DHEA). Circulating DHEA can then be taken up by many tissues such as skin, bone, ovaries or testes and converted to various estrogens and testosterone which can be further converted to dihydrotestosterone (DHT) or estrogen.
Under stress, healthy adrenals will respond by increasing the output of both cortisol and DHEA to higher than normal levels. Such temporary adaptive elevations enable an individual to maintain homeostasis and preserve health in the face of stress. However, if stress becomes chronic, eventually the adrenals can no longer maintain the production of extra DHEA. With continued elevated levels of cortisol and falling DHEA levels, an elevated cortisol-to-DHEA ratio ensues. This signifies an initial stage of adrenal exhaustion and has potentially increasingly, devastating effects. Nutrition may include HPA Axis support, adaptogen botanical, liver, hormonal and electrolytic support, etc, however, the delivery method is key!
When the body makes its own DHEA, it is released into the bloodstream, where it goes straight to the heart. The heart then pumps the unchanged DHEA molecules to every cell in the body so that every cell that can use it gets its supply of these unchanged molecules, and uses them exactly as the cascading natural order intended. Unique target directed, nanosphere liposomes facilitates specific access to the blood stream/heart without having to pass first through the liver. This ensures that the liver does not chemically (Phase I detoxification) modify the bio-hormones prior to reaching their target areas. This is in distinct contrast to tablets or capsules taken orally which are absorbed through the digestive tract and at least partially metabolized by the liver and excreted before they can be made available to the rest of the body. This is known as the “first-pass effect.” Avoiding the first-pass effect is not intended to protect the digestive system or the liver, but to provide greater absorption of the targeted hormones via the now supercharged lymphatic immune cells in the small intestine. In fact, most oral bio-identical hormones or supplements designed to create hormone effects have been shown to produce undesirable changes in C-reactive protein and metabolites from the first-pass effect through the liver.
Ingredients: Niacin (as niacinamide) 5 mg, dehydroepiandrosterone (DHEA) 25 mg, pregnenolone 1 mg.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.